3000 B.C. in the epic of Mahabharata, it is well mentioned that to treat wounded horses and elephants Neem oil and Neem leaves’ preparations were used.  Neem has been used for centuries in various forms to take care of live stock’s health. It has also been very widely used as animal feed. Extracts from Neem bark, leaves, fruits, seeds are used to treat animals. They are used successfully to treat ulcers, skins diseases, intestinal worms, vaccinia virus, variola virus, fowl pox virus, swollen glands, bruises and sprains, antihyperglycaemic effect, cattle filarial parasite Setaria cervi, Livestock insects such as maggots, horn flies, blow flies and biting flies. In the poultry industry, aflatoxicosis caused by Aspergillus flavus in contaminated poultry feed is prevented using neem leaves control mites.

For a biting louse on sheep Azadirachtin is found quite effective as compared to the other synthetic compounds.